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KMID : 0358420050480030695
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Korean Journal of Obstetrics and Gynecology
2005 Volume.48 No. 3 p.695 ~ p.700
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Association of the CYP17 gene polymorphism with the risk of advanced endometriosis in Korean women
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허성은/Hur SE
김미경/이사라/이지영/문혜성/정혜원/Kim MK/Lee SR/Lee JY/Moon HS/Chung HW
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Abstract
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Objective: To investigate whether polymorphism of CYP17 gene is associated with the risk of advanced endometriosis in Korean women.
Methods: The 194 endometriosis patients and 209 controls were enrolled. Blood samples were collected from 194 patients with endometriosis stages III and IV diagnosed by both pathologic and laparoscopic findings. The women undergoing laparoscopic surgery or laparotomy for non-malignant lesions were included in the control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals’ genotype.
Results: The heterozygous allele in CYP17 gene was most common genotypes in both endometriosis and healthy control groups (54.6% vs. 38.8%). In women with heterozygous A1/A2 genotype, there was increased endometriosis risk and this difference was statistically significant (p<0.05).
Conclusion: The results suggest that the CYP17 genetic polymorphism might be associated with advanced endometriosis risk in Korean women.
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KEYWORD
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